Bone Abstracts

Objectives: Association of grip strength (GS) with anthropometric parameters has been reported. Our objective was to assess grip strength in 6 to 18-year-old healthy Indian children (urban and rural) and study the association of GS with body composition.Methods: This was a part of a multicenter, cross-sectional, observational school-based study; multi-stage stratified random sampling was carried out and children (n=1980) from various urban (...

Objective: Children in rural areas have inadequate nutritional intake, hence their muscle function may be compromised. The objective of this study was to study the determinants of muscle function in rural Indian school going children.Methods: We cross sectionally studied 232 prepubertal school going children (106 girls) aged 6–11 years, from 2 different villages in rural area around Pune city in July 2018. Height, weight, body composition (bioelectr...

Objective: Expansion of bone marrow, accumulation of iron, growth failure and delayed puberty affect bone health in thalassemia; data on bone density and geometry are scarce. Our objective was to assess bone density (by Dual Energy X-ray Absorptiometry, DXA) and geometry (by peripheral quantitative computed tomography, pQCT) in children with thalassemia major.Methods: Children with thalassemia were recruited from a hematology clinic in Pune (India) (Mean...

Objectives: i) To assess bone (BMC) by BIA in apparently healthy Indian children. ii) To generate percentile curves for BIA measured BMC by age/gender. iii) To investigate relationship between BMC measured by BIA and DXA in separate subset.Methods: In a multicentre study, 4154 children (2298 boys), 5–18 years underwent BMC assessment by BIA. BMC for age percentiles were computed using LMS method. In 41 children (not from the multicentre study) total...

Objective: Fractures represent a common injury during childhood and adolescence. Knowledge of epidemiology of fractures is crucially important for implementation of prevention strategies for target population. Our objective was to evaluate incidence of fractures in Indian children and adolescents and to investigate association of fractures with physical activity.Methods: Data on history of fracture, age, site of fracture and physical activity were collec...

Objective: Optimal intakes of calcium and milk are necessary in children and adolescents to facilitate not only mineralization but also growth in stature. Low intakes of calcium and also, of milk and milk products in Indian children have been reported. Hence, the objective was to study Indian children’s growth with respect to their calcium and dairy intakes.Methods: We studied 220 children (boys 104, age range 2–16 years). Data on their height,...

Objective: To describe changes in the muscle–bone unit, assessed as the ratio of bone mineral content (BMC) to lean body mass (LBM) at skeletal sites during puberty in Indian males and females, after adjusting for age and fat.Methods: Data on arm, leg and total body (less head) BMC, LBM and fat mass (FM) assessed by DXA for 888 apparently healthy children and adolescents (426 females), 5–17 years of age from a cross-sectional study used to gene...

Objective: Type 1 diabetes mellitus (TIDM) has been shown to adversely affect bone health in children. Hence, objective was to assess bone health status of children with T1DM, and to assess relationship between bone status and disease duration.Methods: Bone mineral content for total body (less head) (TBBMC) and lumbar spine was measured by DXA in 47 (25 boys) children with T1DM. Z-scores for TBBMC for bone area (TBBA), TBBA for height, lean body...

Objective: To study association of VDR gene Fok1 polymorphism locus on bone mass accrual in adolescent girls.Methods: An intervention trial was carried out in 102 girls aged 8–16 years (Pune, India). All girls received 500 mg elemental calcium (daily) and 30 000 IU of vitamin D3 quarterly for 1 year. Outcome variables were measured at baseline and end of the year. Serum levels of ionised calcium (iCa), inorganic phosphorous, parathyroid hor...

Objective: In children, factors such as age and puberty are confounders when investigating associations of fat or lean with bone mineral content (BMC). Our aim was to assess influence of fat on BMC in overweight/obese (ow/ob) and normal weight (nw) children at different stages of puberty.Methods: Cross-sectionally, 244 children+adolescents (6–16 years) (73nw, 177ow/ob) were assessed (tanner staging (TS), body composition (DXA) (total body BMC, lean ...